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专利名称：Reshaped human antibody to human
interleukin-8
发明人：Kouji Matsushima,Yoshihiro
Matsumoto,Yoshiki Yamada,Koh
Sato,Masayuki Tsuchiya,Tatsumi Yamazaki
申请号：US09416557申请日：19991012公开号：US062454B1公开日：20010612
摘要：A reshaped human antibody is characterized as having the same binding affinityfor IL-8 as a chimeric antibody but with low immunogenicity in comparison. The reshapedantibody has the following elements: a human L chain C region or a human L chain FR andan L chain CDR from a mouse monoclonal antibody against human IL-8 and a human Hchain C region or a human H chain FR and an H chain CDR of mouse monoclonal antibodyagainst human IL-8. Since the reshaped human antibody has low immunogenicity tohumans, it is suitable for use in medical treatment of a variety of medical conditions.
申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA
代理机构：Morrison & Foerster LLP
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